Anetoderma is a benign condition with focal loss of collagen or elastic tissue resulting in an area of flaccid skin. Multiple types are described and are classified as primary (unknown cause) or secondary (due to a preceding disorder). Anetoderma of prematurity is a secondary anetoderma occurring in extremely premature (24-29 weeks) infants and considered related to the use of cutaneous monitoring leads or adhesives, as the skin is immature and more susceptible to damage.

Lesions are noted after infants have been in neonatal intensive care units undergoing monitoring. Skin lesions may resolve with time, but the natural history is unknown.