Pictures of ascariasis and disease information have been excerpted from the VisualDx® clinical decision support system as a public health service. Additional information, including symptoms, diagnostic pearls, differential diagnosis, best tests, and management pearls, is available in VisualDx.

Full Clinical Write-up


Ascaris lumbricoides is an intestinal parasite of humans and is the most common human helminthic infection worldwide, estimated to affect more than a billion people. Larvae and adult worms live in the small intestine of humans, and worm eggs are then passed in feces. Infection occurs when infective eggs are ingested, either from putting hands or fingers with contaminated dirt in the mouth or by eating contaminated fruits or vegetables that have not been sufficiently washed, peeled, or cooked. Outdoor defecation or the use of human feces as fertilizer can contaminate the soil with eggs. Eggs can remain viable through extreme temperatures and for several months in sewage.

While currently uncommon in the United States, infection with A lumbricoides (ascariasis) is still prevalent in developing countries. Risk factors include warm and humid climates, poor sanitation, and poor hygiene. Ascaris lumbricoides is thought to cause a major burden of disease worldwide due to acquired nutritional deficiencies (although some studies question whether the degree of nutritional deficiency is a significant factor in the development of disease). However, it is difficult to isolate the burden of disease of A lumbricoides specifically, since many individuals are coinfected with other parasites such as hookworms and whipworms. Young children (namely, preschool and school-aged) tend to carry higher numbers of parasites compared with adults, leading to growth retardation, impaired memory, and worsened cognition.

Ascaris suum is another species of roundworm that primarily infects pigs; humans can become accidental hosts, with organisms developing to the larval tissue-migratory phase but rarely maturing fully. Thus for the purposes of this review, Ascaris will refer to A lumbricoides, which represents the majority of human illness, rather than A suum.

Look For

While many patients will generally be asymptomatic, some will have mild abdominal discomfort or cough (due to part of the life cycle where the worm develops in the lungs and must be coughed and swallowed). Large numbers of Ascaris in the small intestine can lead to abdominal distension, pain, lactose intolerance, and malabsorption of vitamin A and other nutrients.

More serious complications can occur when the organisms migrate out of the jejunum, where the adults normally reside. Intestinal perforation leading to peritonitis and disease of the pancreatobiliary tree (estimated to contribute to more than 35% of cases of biliary or pancreatic disease in Indian subcontinent and parts of Southeast Asia) are two migratory complications. Ascaris can cause intraluminal intestinal obstruction secondary to a mass of worms and can cause occlusion of the appendix.

Abdominal distension, vomiting, diarrhea, signs of sepsis, biliary colic, pneumonia, and a variety of other symptoms can occur depending on worm location.

The full text and image collection is available to VisualDx subscribers.

Prepare for Everything

Get the only system designed for point-of-care visual diagnosis of common and rare medical disorders as well as emerging and re-emerging infectious diseases.

Your first 30 days are free. Cancel any time.

subscribe now