Papular-purpuric gloves and socks syndrome (PPGSS) is a rare dermatosis related to infection with human parvovirus B19. Less common causes include infection with measles, human herpesvirus (HHV)-6, or coxsackie B6. PPGSS is most commonly seen in the spring and summer in young adults. It can, however, be seen in children and adolescents.

A flu-like prodrome of fever, myalgia, lymphadenopathy, and malaise can precede or occur simultaneously with the distinctive cutaneous manifestations. Rapidly progressive, extremely pruritic erythema and swelling of the hands and feet are characteristic. Papular purpura then develops, covering the dorsal and palmoplantar aspects of the hands and feet with sharp demarcation at the wrists and ankles, giving the appearance of being covered by gloves or socks. Patients may report burning and itching.

Most patients also develop an enanthem, which may aid in diagnosis. PPGSS is a self-limited disease, and therapy consists of supportive care and maintenance of adequate fluid intake.