A rare autosomal recessive inherited form of chronic hyperbilirubinemia. Common characteristics include brown or black pigmented parenchymal liver cells and jaundice. Patient may be asymptomatic or present with weakness, abdominal pain, dark urine, jaundice, and icterus. Liver may be somewhat enlarged. Although Dubin-Johnson syndrome may be exacerbated by pregnancy, infection, birth control pills, and alcohol, it is generally benign and has good prognosis. Onset may be in adolescence, adulthood, and in some cases, infancy. Although it may occur in all ethnicities, it appears more commonly in Iranian, Iraqi, and Moroccan Jews.