An insulinoma is a rare insulin-producing neuroendocrine tumor arising from the beta cells of the pancreas. It is typically detected due to hyperinsulinemic hypoglycemia. The majority are benign. Common findings, besides hypoglycemia, include confusion, memory loss, diaphoresis, blurred vision, weight gain, weakness, dysarthria, tachycardia, palpitations, tremors, syncope, seizures, and coma. These symptoms typically develop for years before the affected patient is diagnosed. Risk factors include multiple endocrine neoplasia type 1 and von Hippel-Lindau syndrome.

Surgery is the treatment of choice. Some severe cases may require partial or complete pancreatectomy.