Contents

SynopsisCodesDifferential Diagnosis & PitfallsBest TestsDrug Reaction DataReferences
Drug-induced syncope
Other Resources UpToDate PubMed

Drug-induced syncope

Contributors: Christine Osborne MD, Richard L. Barbano MD, PhD
Other Resources UpToDate PubMed

Synopsis

Both syncope due to cardiac arrhythmias and syncope due to orthostatic hypotension can be the result of medication. Medications that lead to bradycardia, such as beta blockers, or tachyarrhythmias, such as sodium channel blockers, or medications that prolong the QT interval may cause syncope. In addition, orthostatic hypotension may occur in the setting of antihypertensives, peripheral vasodilators, diuretics, phenothiazines, and antidepressants. The orthostatic effects are particularly strong with volume depletion, dehydration, or exposure of elderly individuals to dry, hot weather. Alcohol and other illicit drugs may lead to syncope via both arrhythmias and orthostatic hypotension.

Codes

ICD10CM:
R55 – Syncope and collapse
T50.905A – Adverse effect of unspecified drugs, medicaments and biological substances, initial encounter

SNOMEDCT:
271594007 – Syncope
278993004 – Drug-induced

Differential Diagnosis & Pitfalls

To perform a comparison, select diagnoses from the classic differential

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Best Tests

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Drug Reaction Data

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References

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Last Updated:09/02/2015
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Drug-induced syncope
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A medical illustration showing key findings of Drug-induced syncope : Syncope
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