Corticobasal syndrome, also known as corticobasal ganglionic degeneration, is a rare neurodegenerative disorder characterized by progressive movement and cognitive dysfunction. Symptoms are often asymmetric at onset and include parkinsonism (bradykinesia and rigidity), dystonia, myoclonus, apraxia, aphasia, and/or alien limb syndrome. Patients may also present with cognitive, behavioral, or language changes. Typical age of onset is 45-70, and average duration is 6-8 years.

Early on, this disease may be hard to differentiate from other dementias or parkinsonian disorders. There can be clinical overlap with progressive supranuclear palsy and frontotemporal dementias.