Dyshidrotic dermatitis (dyshidrotic eczema, pompholyx) is generally defined as a recurrent vesicular eruption limited to the hands (most often the sides of the digits) and sometimes the feet. The lesions are extremely pruritic. The etiology is unknown; no causal relationship with sweating has been shown. There is no sex predilection.

Dyshidrotic dermatitis is rare in younger children. When arising in the pediatric population, it is generally seen after the age of 10. The condition often presents episodically, more commonly in warm weather.

Dyshidrotic eczema has been associated with atopic dermatitis, contact irritants and allergens, dermatophyte and bacterial infections, hyperhidrosis, hot weather, diet, and emotional stress. Administration of intravenous immunoglobulin (IVIG) has been associated with severe dyshidrotic dermatitis. There have also been a few reports of dyshidrotic dermatitis in adults treated with secukinumab.

Some cases spontaneously resolve. Treatment is aimed at symptomatic relief and control of vesiculation.