Condyloma acuminata are warts that occur secondary to infection with the human papillomavirus (HPV), a double-stranded DNA that belongs to the family of Papillomaviridae. The incubation period from exposure to lesion development can last from months to years. High-risk and low-risk genotypes of HPV have been identified based on their prevalence in intraepithelial neoplasia and carcinomas. High-risk genotypes include types 16, 18, 31, 33, and 35, and low-risk genotypes include types 6 and 11.

Transmission of HPV infection can occur through either direct contact, autoinoculation, or fomite transfer. The average incubation period for warts ranges from 2-3 months but can extend to 1 year. Most lesions are symptomless; however, associated symptoms can include itching and bleeding.

The highest risk population for HPV infection is sexually active women younger than 26 years. However, HPV infection can affect patients of any sex and a wide span of ages from infants to the elderly.

In immunosuppressed patients, warts proliferate due to suppressed cellular immunity and carry a risk of carcinogenesis. An increased prevalence of anogenital warts is noted in this population. Recurrences are common and response to treatment is impaired.

Related topic: oral mucosal wart