Myelofibrosis
Alerts and Notices
Important News & Links
Synopsis
The peripheral blood smear often demonstrates leukoerythroblastic changes and teardrop-shaped red blood cells (RBCs), consistent with bone marrow fibrosis. As the marrow is replaced by fibrosis, the spleen will enlarge due to extramedullary hematopoiesis.
The bone marrow biopsy may be a "dry tap" due to extensive fibrosis and/or osteosclerosis replacing the marrow elements. Up to 60% of cases of myelofibrosis contain the JAK2 V617F mutation (which can be detected on peripheral blood or bone marrow).
Myelofibrosis is a chronic condition with many phases. When the disease is more progressed, there is a possibility it may transform into acute leukemia.
Codes
D75.81 – Myelofibrosis
SNOMEDCT:
52967002 – Myelofibrosis
Look For
Subscription Required
Diagnostic Pearls
Subscription Required
Differential Diagnosis & Pitfalls
Subscription Required
Best Tests
Subscription Required
Management Pearls
Subscription Required
Therapy
Subscription Required
Drug Reaction Data
Subscription Required
References
Subscription Required
Last Updated:11/08/2017