Contents

SynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyDrug Reaction DataReferences

View all Images (14)

Crohn disease - Anogenital in
See also in: Overview,Oral Mucosal Lesion
Other Resources UpToDate PubMed

Crohn disease - Anogenital in

See also in: Overview,Oral Mucosal Lesion
Contributors: Mitchell Linder MD, Michael W. Winter MD, Susan Burgin MD
Other Resources UpToDate PubMed

Synopsis

Crohn disease is a disease of chronic inflammation in the gastrointestinal tract that can involve anywhere from the mouth to the anus. It is characterized by transmural inflammation and often noncaseating granulomas. The etiology is unclear, but it is likely triggered by a combination of genetic and environmental factors, with mucosal injury caused in part by immune activation against healthy intestinal microbiota.

Symptoms from Crohn disease can vary considerably, both due to location but also to the severity of disease involvement. Patients may present with abdominal pain, bloody or nonbloody diarrhea, weight loss or malnutrition, fistulas, abscesses (often perianal), dysphagia, or oral ulcerations. Additionally, Crohn disease has many extraintestinal manifestations that can at times be the presenting symptoms. These manifestations can involve joints, skin, eyes, vasculature, the lungs, or the kidneys.

Crohn disease may involve the vulva and groin in 22%-44% of cases, either primarily or secondarily. Granulomatous infiltration of genital skin may compress lymphatics, leading to lymphedema of the vulva. Linear ulceration or aphthae may be present. True fistulas may occur. Hidradenitis suppurativa may be associated.

Crohn disease presents most typically in the second to fourth decades of life, with a slight female predominance. While no clear genetic mutation is linked to the development of Crohn disease, there are many genetic mutations that are associated with Crohn disease. For unclear reasons, Crohn disease is more prevalent at higher latitudes and in certain patient populations, namely individuals of Ashkenazi Jewish descent and individuals of Northern European descent in the United States.

Codes

ICD10CM:
K50.918 – Crohn's disease, unspecified, with other complication

SNOMEDCT:
34000006 – Crohn's disease

Look For

Subscription Required

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

To perform a comparison, select diagnoses from the classic differential

Subscription Required

Best Tests

Subscription Required

Management Pearls

Subscription Required

Therapy

Subscription Required

Drug Reaction Data

Subscription Required

References

Subscription Required

Last Reviewed:01/02/2019
Last Updated:02/29/2024
Copyright © 2024 VisualDx®. All rights reserved.
Crohn disease - Anogenital in
See also in: Overview,Oral Mucosal Lesion
Clinical image of Crohn disease - imageId=248831. Click to open in gallery.  caption: 'Scarring and tunnels on the inner, upper thigh and labium majus (hidradenitis suppurativa in a patient with Crohn disease).'
Scarring and tunnels on the inner, upper thigh and labium majus (hidradenitis suppurativa in a patient with Crohn disease).
Copyright © 2024 VisualDx®. All rights reserved.