Neutrophilic eccrine hidradenitis is a disorder characterized by toxic injury to eccrine coils resulting in erythematous or purpuric lesions on the trunk, limbs, neck, face, scalp, and/or ears. The disorder is most frequently associated with chemotherapy, but may be associated with other etiologies:

• Predisposing medications, including cytarabine, mitoxantrone, bleomycin, and other chemotherapy agents, but not limited to this class. Other triggers include acetaminophen, carbamazepine, and granulocyte colony-stimulating factor (G-CSF); this reaction typically occurs 8-10 days after initiation of the drug.
• A paraneoplastic phenomenon, as it has been reported with myeloproliferative and lymphoproliferative malignancy as well as solid organ malignancies (such as osteosarcoma, testicular carcinoma, metastatic breast cancer, and Wilms tumor) without preceding chemotherapy.
• Human immunodeficiency virus (HIV) and Behçet disease.
• Rarely, with bacterial infection (Serratia, Staphylococcus, Enterobacter, and Nocardia).

Patients may present with fever, neutropenia, lesion pruritus, and pain and tenderness. Lesions are usually self-limited and rarely will recur with subsequent drug exposure.