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Fox-Fordyce disease
See also in: Anogenital
Other Resources UpToDate PubMed

Fox-Fordyce disease

See also in: Anogenital
Contributors: Vivian Wong MD, PhD, Mat Davey MD, Mary Gail Mercurio MD, Susan Burgin MD
Other Resources UpToDate PubMed

Synopsis

Fox-Fordyce disease is a rare inflammatory condition of apocrine gland-bearing regions caused by obliteration of the follicular infundibulum with keratin. The etiology is unknown, although an endocrine role has been postulated. The disease manifests as intensely pruritic, skin-colored or keratotic papules in the axillary, anogenital, umbilical, and periareolar areas. Heat, humidity, stress, and other external stimuli such as laser hair removal may worsen symptoms and lead to appearance of new papules.

It is most common in females between puberty and age 35. Less commonly, it can affect male patients, prepubescent girls, and postmenopausal women. It may flare perimenstrually and improve during pregnancy and after menopause.

Codes

ICD10CM:
L75.2 – Apocrine miliaria

SNOMEDCT:
65038009 – Fox-Fordyce disease

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Last Reviewed:01/31/2021
Last Updated:01/31/2021
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Patient Information for Fox-Fordyce disease
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Contributors: Lindsey Ayanruoh, Chesahna Kindred MD
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Fox-Fordyce disease
See also in: Anogenital
A medical illustration showing key findings of Fox-Fordyce disease : Areola, Axilla, Female genital, Follicular configuration, Intertriginous distribution, Pruritus, Tiny papules
Clinical image of Fox-Fordyce disease - imageId=96390. Click to open in gallery.  caption: 'Numerous hyperpigmented, monomophic, follicular-based papules in the axilla.'
Numerous hyperpigmented, monomophic, follicular-based papules in the axilla.
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