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Lipoatrophy in Adult
Other Resources UpToDate PubMed

Lipoatrophy in Adult

Contributors: Amy Fox MD, David Dasher MD, Lowell A. Goldsmith MD, MPH
Other Resources UpToDate PubMed

Synopsis

Lipoatrophy is thought to be a postinflammatory state where there is loss of subcutaneous fat. Predisposing conditions for lipoatrophy include panniculitis, exogenous pressure, injection of medication, and antiretroviral therapy for HIV. Lipoatrophy is also a normal contributor to the appearance of an aging face.

Localized lipoatrophy has been subcategorized into the following: annular, abdominal, semicircular, and postinjection. These subcategories aim to describe clinical presentation, with the exception of postinjection lipoatrophy. The cause of lipoatrophy in annular, abdominal, and semicircular categories is thought to be postinflammatory.

Injection site lipoatrophy can be associated with insulin, corticosteroids, and antibiotics, among others, and history is a key component of making this diagnosis. Lipoatrophy associated with HIV is thought to result from antiretroviral treatment, although the exact mechanism is unknown.

Codes

ICD10CM:
E88.1 – Lipodystrophy, not elsewhere classified

SNOMEDCT:
248315005 – Lipoatrophy

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Last Updated:09/30/2019
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Lipoatrophy in Adult
A medical illustration showing key findings of Lipoatrophy : Atrophy
Clinical image of Lipoatrophy - imageId=4420916. Click to open in gallery.  caption: 'Loss of girth of the right leg, secondary to lipoatrophy.'
Loss of girth of the right leg, secondary to lipoatrophy.
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