Malakoplakia
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Synopsis
Malakoplakia may occur at any age, but it classically affects middle-aged women. Children are rarely affected. Most cases reported occurred in immunocompromised patients, including those with malignancy, hypogammaglobulinemia, autoimmune disorders such as rheumatoid arthritis, or chronic conditions such as diabetes mellitus, HIV / AIDS, and post-organ transplantation, primarily kidney transplants. Malakoplakia has only rarely been reported in immunocompetent individuals.
Malakoplakia, from the Greek malako meaning "soft" and plako meaning "plaque," typically presents with soft, friable mucosal papules, plaques, or nodules that predominantly affect the genitourinary tract. Patients may be asymptomatic or present with pain and fever, with additional findings depending on the organ systems affected. Genitourinary tract involvement classically presents in a middle-aged woman with dysuria, recurrent urinary tract infections (UTIs), hematuria, and abdominal pain.
Cutaneous malakoplakia manifests in the perineal and genital regions as friable papules or nodules, abscesses, draining sinuses, or ulcers.
Codes
N36.8 – Other specified disorders of urethra
SNOMEDCT:
716766007 – Malakoplakia
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Last Updated:01/16/2020