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Nevus anemicus in Adult
Other Resources UpToDate PubMed

Nevus anemicus in Adult

Contributors: Nnenna Agim MD, FAAD, Catherine Chung MD, Susan Burgin MD
Other Resources UpToDate PubMed

Synopsis

Nevus anemicus is a cutaneous finding characterized by focal pallor of skin without textural irregularity due to congenital local hypersensitivity of cutaneous blood vessels to catecholamines. The vasoconstriction and subsequent pallor of the affected skin mimics hypopigmentation, but this usually congenital change has no associated pigmentary alteration. Nevus anemicus usually involves the trunk, but lesions on the face and extremities have been observed. It is usually first noticed at birth or in early childhood, but because it can often be subtle and is asymptomatic, it is frequently an isolated incidental finding.

Nevus anemicus may also occur in association with several syndromes, including neurofibromatosis (up to 4% of cases) and phakomatosis pigmentovascularis (PPV), a syndrome consisting of combinations of cutaneous and vascular findings that may include capillary malformations, dermal melanocytosis, and nevus spilus, caused by mutations in the GNAQ / GNA11 pathways. Nevus anemicus has also been seen in patients with Legius syndrome with confirmed SPRED1 mutation and Noonan syndrome with lentigines, with a confirmed PTPN11 mutation.

Codes

ICD10CM:
Q82.5 – Congenital non-neoplastic nevus

SNOMEDCT:
40929003 – Nevus anemicus

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Last Reviewed:07/26/2021
Last Updated:08/05/2021
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Nevus anemicus in Adult
A medical illustration showing key findings of Nevus anemicus : Present at birth
Clinical image of Nevus anemicus - imageId=93049. Click to open in gallery.  caption: 'A white patch with scalloped borders and faint surrounding erythema on the chest.'
A white patch with scalloped borders and faint surrounding erythema on the chest.
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