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Infiltrating basal cell carcinoma
See also in: Hair and Scalp
Other Resources UpToDate PubMed

Infiltrating basal cell carcinoma

See also in: Hair and Scalp
Contributors: Yevgeniy Balagula MD, Susan Burgin MD, Gaurav Singh MD, MPH, William M. Lin MD, Sarah Hocker DO, Belinda Tan MD, PhD
Other Resources UpToDate PubMed

Synopsis

Basal cell carcinoma (BCC) is the most common cancer in humans and the most common cancer of the skin. Two million Americans are diagnosed with BCC every year. It is a neoplasm of basal keratinocytes that is found more frequently in men than women. Rates of BCC have been increasing over the last several decades, particularly in young women. Nonetheless, the malignancy has greater incidence in older individuals, with a median age at diagnosis of 68 years. There are many subtypes of BCC, including nodular, superficial, infundibulocystic, fibroepithelial, morpheaform (sclerosing, desmoplastic), infiltrative, micronodular, and basosquamous. Infiltrating BCCs are less common but tend to be more aggressive with local tissue invasion.

The most prevalent risk factor contributing to the development of BCCs is sun exposure, and people with light skin phototypes are at higher risk. Intermittent sun exposure is more associated with the development of BCCs than cumulative ultraviolet (UV) exposure. Notably, BCCs can occur on any hair-bearing site but are most commonly found on the face.

Other risk factors for BCCs include environmental exposure (ie, ionizing radiation, indoor tanning, chemicals such as arsenic, psoralen plus UVA, and coal tar), phenotype (freckling, red hair, light skin that always burns and never tans), immunosuppression such as organ transplantation (which results in a 5-10 times higher risk of BCCs than the general population), and various genetic syndromes including xeroderma pigmentosum, oculocutaneous albinism, Muir-Torre syndrome, basal cell nevus syndrome (Gorlin syndrome), Rombo syndrome, and Bazex-Dupré-Christol syndrome. The gene most frequently altered in BCCs is the PTCH1 gene, followed by the TP53 gene.

Although BCCs are almost never fatal, local tissue destruction and disfiguration occur. The metastasis rate of BCCs is approximately 1 in 35 000. Metastasis is rare and typically occurs through perineural spread, lymph node metastasis, and then lung / bone metastasis.

Codes

ICD10CM:
C44.91 – Basal cell carcinoma of skin, unspecified

SNOMEDCT:
402527000 – Basal cell carcinoma - infiltrative

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Last Reviewed:12/19/2018
Last Updated:01/29/2023
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Infiltrating basal cell carcinoma
See also in: Hair and Scalp
A medical illustration showing key findings of Infiltrating basal cell carcinoma : Face, Pink color, Skin ulcer, Atrophic scar, Sun-exposed distribution
Clinical image of Infiltrating basal cell carcinoma - imageId=88519. Click to open in gallery.  caption: 'A close-up of a shiny, whitish-pink plaque with a central depressed erosion and scale.'
A close-up of a shiny, whitish-pink plaque with a central depressed erosion and scale.
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