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Drug-induced non-palpable purpura in Adult
Other Resources UpToDate PubMed

Drug-induced non-palpable purpura in Adult

Contributors: Michael D. Tharp MD, Neil Shear MD
Other Resources UpToDate PubMed

Synopsis

Petechiae and non-palpable purpura (ecchymoses) secondary to medications occur as a result of hemorrhage into the skin. Medications that cause thrombocytopenia or alter platelet function manifest with petechiae and ecchymoses. Chemotherapeutic agents can cause generalized bone marrow suppression leading to thrombocytopenia. Bleomycin has been reported to cause endothelial damage and leakage resulting in purpura.

Uncommonly, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors have been associated with purpuric skin lesions on the lower extremities, including purpuric macules or papules with confluent plaques, sometimes in an annular configuration; non-follicular purpuric pustules; and xerotic purpuric lesions. See also EGFR inhibitor-induced eruption.

Drug-induced thrombotic thrombocytopenic purpura (TTP) may occur secondary to medication use. It is a life-threatening, multisystem disease. There is strong literature evidence of ticlopidine as a trigger of TTP. Other triggers of TTP frequently reported include interferon alpha (IFN-alpha) therapy, cyclosporine, quinine, and clopidogrel.

Codes

ICD10CM:
L27.1 – Localized skin eruption due to drugs and medicaments taken internally

SNOMEDCT:
109957002 – Drug-induced purpura

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Last Updated:09/18/2017
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Drug-induced non-palpable purpura in Adult
A medical illustration showing key findings of Drug-induced non-palpable purpura : Cayenne pepper like purpura, Erythema, Scattered many, Symmetric extremities distribution, Ecchymosis
Clinical image of Drug-induced non-palpable purpura - imageId=369027. Click to open in gallery.  caption: 'Showers of discrete and confluent petechiae and purpura on the foot.'
Showers of discrete and confluent petechiae and purpura on the foot.
Copyright © 2024 VisualDx®. All rights reserved.