The interstitial granulomatous drug reaction (IGDR) is a skin eruption with distinctive clinical and histopathological findings. Lesions are usually localized to skin folds, are asymptomatic, and may not begin until several weeks, months, or even years after drug initiation. Most lesions resolve over weeks following drug cessation. The exact mechanism is unknown.
Calcium channel blockers, angiotensin-converting enzyme (ACE) inhibitors, lipid-lowering agents, antihistamines (H2 receptor antagonists), furosemide, carbamazepine, anti-tumor necrosis factor (TNF) agents, bupropion and tricyclic antidepressants, and soy have all been implicated.
Related topic: Interstitial granulomatous dermatitis
Interstitial granulomatous drug reaction
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Synopsis
Codes
ICD10CM:
L27.1 – Localized skin eruption due to drugs and medicaments taken internally
SNOMEDCT:
81119003 – Dermatitis due to drug AND/OR medicine taken internally
L27.1 – Localized skin eruption due to drugs and medicaments taken internally
SNOMEDCT:
81119003 – Dermatitis due to drug AND/OR medicine taken internally
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Last Reviewed:07/11/2018
Last Updated:07/11/2018
Last Updated:07/11/2018
Interstitial granulomatous drug reaction
