Periorificial dermatitis, also known as perioral dermatitis, is a benign inflammatory eruption characterized by erythematous papules and pustules around the mouth, periorbital, and/or perinasal areas. Lesions are typically asymptomatic but may be mildly pruritic. This summary addresses periorificial dermatitis in children. Periorificial dermatitis in adults is addressed separately.

Childhood granulomatous periorificial dermatitis (CGPD) is an uncommon granulomatous variant of periorificial dermatitis. CGPD predominantly affects prepubertal children and is thought to be more common among individuals with darker skin colors, although cases have been reported in individuals with lighter skin as well. CGPD is characterized by mildly pruritic, yellowish-to-brown papules and may wax and wane for years.

Development of periorificial dermatitis is often preceded by exposure to topical corticosteroids on the face. Inhaled and systemic corticosteroids have also been associated with periorificial dermatitis. Exposure to peppermint oil as well as various cosmetic products, including fluorinated toothpastes, have also been reported as potential precipitants of this condition.

Patients with periorificial dermatitis may develop intraocular manifestations such as conjunctivitis or blepharitis.