Peripheral giant cell granuloma - Oral Mucosal Lesion
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Synopsis
The peripheral giant cell granuloma is a fairly common nodule on the gingiva caused by a proliferation of giant cells. It is likely caused by gingival and/or periodontal inflammation that results in differentiation of pluripotent cells into osteoclast-like or monocyte-like cells.
It tends to occur in older individuals in the fifth and sixth decades with a slight female predilection. The mandibular gingiva is more often involved than the maxillary. It is usually non-painful. Biting on it may induce bleeding since it is contains many blood vessels. It often occurs in the edentulous ridge. The lesion may lie in a cup-shaped depression in the underlying bone. Sometimes it may be difficult to tell if this is a purely extra-osseous process that has cupped the bone or whether it is an intra-osseous central giant cell granuloma that has broken through the bone and now has an extra-osseous or "peripheral" presentation. Unlike the central giant cell granulomas, these are not usually associated with hyperparathyroidism.
It tends to occur in older individuals in the fifth and sixth decades with a slight female predilection. The mandibular gingiva is more often involved than the maxillary. It is usually non-painful. Biting on it may induce bleeding since it is contains many blood vessels. It often occurs in the edentulous ridge. The lesion may lie in a cup-shaped depression in the underlying bone. Sometimes it may be difficult to tell if this is a purely extra-osseous process that has cupped the bone or whether it is an intra-osseous central giant cell granuloma that has broken through the bone and now has an extra-osseous or "peripheral" presentation. Unlike the central giant cell granulomas, these are not usually associated with hyperparathyroidism.
Codes
ICD10CM:
K13.4 – Granuloma and granuloma-like lesions of oral mucosa
SNOMEDCT:
89722009 – Giant cell peripheral granuloma
K13.4 – Granuloma and granuloma-like lesions of oral mucosa
SNOMEDCT:
89722009 – Giant cell peripheral granuloma
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Last Updated:11/13/2013
Peripheral giant cell granuloma - Oral Mucosal Lesion