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Bullous hemorrhagic dermatosis
Other Resources UpToDate PubMed

Bullous hemorrhagic dermatosis

Contributors: Erin X. Wei MD, Kira Blair Mayo MD, Susan Burgin MD
Other Resources UpToDate PubMed

Synopsis

Bullous hemorrhagic dermatosis (BHD) is a non-life-threatening side-effect from administration of low-molecular weight heparin (eg, enoxaparin, dalteparin, tinzaparin, bemiparin), heparin, and unfractionated heparin, characterized by multiple tense, blood-filled vesicles or bullae near or distant from the site of injection. It is most commonly associated with enoxaparin use, which accounts for over 60% of cases reported in the literature. BHD has also been reported with fondaparinux and warfarin use.

Those affected are typically in their 60s to 80s, which may reflect the typical age of anticoagulant use, with a male to female ratio of 1.9 to 1. The lesions typically appear 2-20 days (median 7 days) after initiation of anticoagulant treatment. There are over 90 cases reported in literature, but BHD may be underreported.

The etiology of BHD is poorly understood.

Codes

ICD10CM:
L13.9 – Bullous disorder, unspecified

SNOMEDCT:
402750008 – Bullous dermatosis precipitated by drug treatment

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Last Reviewed:02/05/2020
Last Updated:02/05/2020
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Bullous hemorrhagic dermatosis
A medical illustration showing key findings of Bullous hemorrhagic dermatosis : heparin group
Clinical image of Bullous hemorrhagic dermatosis - imageId=3791721. Click to open in gallery.  caption: 'A close-up of numerous hemorrhagic vesicles and bullae, and early crusting, in a patient on an anticoagulant.'
A close-up of numerous hemorrhagic vesicles and bullae, and early crusting, in a patient on an anticoagulant.
Copyright © 2024 VisualDx®. All rights reserved.