Reversible posterior leukoencephalopathy syndrome
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Synopsis
Physical examination often reveals hypertension and detectable visual perception abnormalities, including hemianopia, cortical blindness, or visual neglect. Reflexes are brisk and Babinski sign is often present. Risk factors for development of RPLS include hypertension, eclampsia, and immunosuppressive therapy, especially cyclosporine, tacrolimus, sirolimus, cisplatin, and rituximab.
Treatment is aimed at the precipitating cause, and prompt treatment is necessary given the potentially reversible nature of the condition. Onset is usually over hours to a day. Most patients recover within 2 weeks, with few patients having residual neurologic deficits.
Codes
I67.83 – Posterior reversible encephalopathy syndrome
SNOMEDCT:
450886002 – Posterior reversible encephalopathy syndrome
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Last Updated:07/09/2018