Drug-induced hyperlipasemia refers to an elevation of lipase attributed to a medication or other drug exposure. Importantly, this does not indicate pancreatitis, as pancreatitis requires 2 of 3 criteria: (1) lipase over 3 times the upper limit of normal, (2) imaging findings suggestive of pancreatitis, and (3) clinical examination consistent with pancreatitis.
Narcotics, thiazide diuretics, oral contraceptives, adrenocorticotropic hormone, and cholinergics are commonly associated with hyperlipasemia. For a list of medications associated with drug-induced hyperlipasemia, see Drug Reaction Data below.
Benign lipasemia will be asymptomatic. If lipase is elevated in the setting of drug-induced pancreatitis, patients will often present with nausea, emesis, and mid-epigastric abdominal pain radiating to the back.
Drug-induced hyperlipasemia
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Synopsis
Codes
ICD10CM:
R74.8 – Abnormal levels of other serum enzymes
T50.995A – Adverse effect of other drugs, medicaments and biological substances, initial encounter
SNOMEDCT:
278993004 – Drug-induced
441957004 – High lipase level in serum
R74.8 – Abnormal levels of other serum enzymes
T50.995A – Adverse effect of other drugs, medicaments and biological substances, initial encounter
SNOMEDCT:
278993004 – Drug-induced
441957004 – High lipase level in serum
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Last Reviewed:01/01/2018
Last Updated:08/21/2018
Last Updated:08/21/2018