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SynopsisCodesDifferential Diagnosis & PitfallsBest TestsDrug Reaction DataReferences
Drug-induced hyperamylasemia
Other Resources UpToDate PubMed

Drug-induced hyperamylasemia

Contributors: Benjamin L. Mazer MD, MBA
Other Resources UpToDate PubMed

Synopsis

Hyperamylasemia is an abnormally high level of the enzyme amylase in the blood. Amylase is a crucial enzyme in the metabolism of starches. It is physiologically most abundant in the pancreas and salivary glands, but many other organs produce some quantity of the enzyme. Injury to these organs may lead to hyperamylasemia. Pancreatitis, diabetic ketoacidosis, and malignancy are among the common causes of hyperamylasemia. Drugs, however, may induce injury to amylase-containing tissue or change serum binding of amylase, resulting in hyperamylasemia. Drugs reported to have caused hyperamylasemia include opiates, acetaminophen, lamivudine, and valproic acid.

Codes

ICD10CM:
R74.8 – Abnormal levels of other serum enzymes
T50.995A – Adverse effect of other drugs, medicaments and biological substances, initial encounter

SNOMEDCT:
275739007 – Serum amylase raised
278993004 – Drug-induced

Differential Diagnosis & Pitfalls

To perform a comparison, select diagnoses from the classic differential

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Best Tests

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Drug Reaction Data

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References

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Last Updated:12/22/2015
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Drug-induced hyperamylasemia
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A medical illustration showing key findings of Drug-induced hyperamylasemia
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