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Contents

Synopsis Codes Best Tests References

Quebec platelet disorder

Contents

Synopsis Codes Best Tests References

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Quebec platelet disorder

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Synopsis

Quebec platelet disorder : Bleeding time prolonged, Easy bruising, Fibrinogen decreased, Hemarthrosis, Epistaxis, PLT decreased

A partial duplication of PLAU (plasminogen activator urokinase type) in platelets leads to a dominant gain-of-function mutation with delayed bleeding after challenges such as surgery. The increased PLAU levels in platelets increase plasmin generation degradation of alpha-granule proteins. Responds to fibrinolytic inhibitors.

Codes

ICD10CM:
D68.2 – Hereditary deficiency of other clotting factors

SNOMEDCT:
128101008 – Platelet factor V deficiency (factor V Quebec)

Best Tests

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Last Updated:01/23/2022

Quebec platelet disorder

A medical illustration showing key findings of Quebec platelet disorder : Bleeding time prolonged, Easy bruising, Fibrinogen decreased, Hemarthrosis, Epistaxis, PLT decreased

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