Minimal change disease
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Synopsis
The most common cause of nephrotic syndrome in children, this glomerular disease is characterized by normal glomerular appearance by light microscopy, no immune complexes on immunofluorescence, and diffuse podocyte foot process effacement on electron microscopy. Minimal change disease can also present in adulthood and is classically very responsive to steroids. The pathophysiology is not clear, but T-cell dysfunction is thought to be a significant factor.
Codes
ICD10CM:
N05.0 – Unspecified nephritic syndrome with minor glomerular abnormality
SNOMEDCT:
44785005 – Minimal change disease
N05.0 – Unspecified nephritic syndrome with minor glomerular abnormality
SNOMEDCT:
44785005 – Minimal change disease
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Last Updated:02/11/2016
Minimal change disease