A rare genetic disorder that inhibits coagulation due to the production of defective fibrinogen. In most cases, it is autosomal dominantly inherited. The majority of cases are asymptomatic and require no treatment. Symptomatic cases can present with multiple prolonged bleeding events, bleeding diathesis, pulmonary embolism, thrombosis, thromboembolic events, poor wound healing, and increased rates of spontaneous abortion. Tests positive for prolonged thrombin time and reptilase time may aid diagnosis. Treatment includes fibrinogen replacement therapy.

Dysfibrinogenemia can also be acquired.