Contents

SynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyDrug Reaction DataReferences

View all Images (4)

Papuloerythroderma of Ofuji
Other Resources UpToDate PubMed

Papuloerythroderma of Ofuji

Contributors: Nasro Isaq, Susan Burgin MD
Other Resources UpToDate PubMed

Synopsis

Papuloerythroderma of Ofuji (PEO) is a rare form of erythroderma, most commonly seen in older men. It begins with pruritic, erythematous or brown, flat-topped papules that subsequently coalesce into plaques. The plaques eventually generalize into near-global erythroderma sparing the skin folds, a characteristic physical finding known as the deck-chair sign. Most patients present with associated pruritus and peripheral eosinophilia, while elevated immunoglobulin E (IgE) level and peripheral lymphopenia are less frequently observed. Reactive lymphadenopathy may be present.

PEO mostly affects men of Asian or Northern European descent, with onset at age 55 years or older. These patients are typically healthy, and PEO is usually idiopathic. However, etiological associations have been noted in a minority of cases, including an underlying atopic diathesis, hematologic malignancies, gastric and other solid organ malignancies, and, less frequently, drugs (such as aspirin and furosemide) and infections (such as hepatitis C virus [HCV] and human immunodeficiency virus [HIV]). Additionally, cases of cutaneous T-cell lymphoma (CTCL) with a PEO-like clinical appearance have been reported.

PEO is generally an indolent condition and requires long-term treatment. Those with secondary PEO may experience faster and complete resolution upon treatment of underlying conditions or cessation of offending drugs.

Codes

ICD10CM:
L53.9 – Erythematous condition, unspecified

SNOMEDCT:
402299006 – Papuloerythroderma of Ofuji

Look For

Subscription Required

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

To perform a comparison, select diagnoses from the classic differential

Subscription Required

Best Tests

Subscription Required

Management Pearls

Subscription Required

Therapy

Subscription Required

Drug Reaction Data

Subscription Required

References

Subscription Required

Last Reviewed:08/18/2019
Last Updated:08/29/2019
Copyright © 2024 VisualDx®. All rights reserved.
Papuloerythroderma of Ofuji
A medical illustration showing key findings of Papuloerythroderma of Ofuji : Eosinophilia, Erythroderma, Trunk, Widespread distribution, Pruritus, Smooth papules
Copyright © 2024 VisualDx®. All rights reserved.