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Apocrine adenocarcinoma
Other Resources UpToDate PubMed

Apocrine adenocarcinoma

Contributors: Michelle Boettler, Martha Hickmann MD, FAAD, Susan Burgin MD
Other Resources UpToDate PubMed

Synopsis

Apocrine adenocarcinoma (AA) of the skin (also known as apocrine gland carcinoma, cutaneous apocrine carcinoma, primary apocrine adenocarcinoma, primary apocrine gland carcinoma, or primary cutaneous apocrine adenocarcinoma) is a rare malignant neoplasm of the apocrine sweat gland. It most commonly arises in the axillae, but AA may also occur on the nipples, scalp, face, trunk, and extremities. Eyelid lesions are thought to arise from the glands of Moll. The pathogenesis is unknown. To date, limited data exist on the epidemiology of this rare disease, its prognosis, and its treatment. 

The peak incidence is during middle age, and there is a slight male predominance. There is no racial predilection.

The clinical presentation of AA is variable. It typically presents as a solitary, asymptomatic, erythematous or violaceous nodule that measures 2-3 cm. It can grow slowly, or it may be rapidly progressive and aggressive.

Typical locations are those with high apocrine gland density, such as the axillae. However, lesions can occur anywhere on the skin because of the presence of ectopic apocrine glands. A case arising in an accessory nipple in the axilla and one arising in a nevus sebaceus have been reported. Tumors arising in the anogenital region may be considered as carcinomas of the anogenital region by some pathologists.

Codes

ICD10CM:
C44.99 – Other specified malignant neoplasm of skin, unspecified

SNOMEDCT:
57141000 – Apocrine adenocarcinoma

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Last Reviewed:09/02/2020
Last Updated:09/02/2020
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Apocrine adenocarcinoma
A medical illustration showing key findings of Apocrine adenocarcinoma : Axilla
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