Drug-induced urine color change is an abnormal urine discoloration that may be caused by numerous drugs.

Normal urine ranges from clear to dark yellow in color, depending on its concentration. Abnormal urine discoloration can occur in a range of different colors: black, blue, brown, green, orange, pink, and red. Urine color changes can result from edible dyes and other compounds found in medications and food. Urine color changes may also be caused by strenuous exercise, or may occur due to pathological processes.

Certain classes of drugs are more commonly implicated in causing urine color changes, including anesthetics, antibiotics, anticonvulsants, antimalarials, chelating agents, diuretics, multivitamins, muscle relaxants, oxidation-reduction agents, and urinary analgesics. Indigo carmine food colorant is a common causative agent.