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Chronic ulcerative stomatitis - Oral Mucosal Lesion
Other Resources UpToDate PubMed

Chronic ulcerative stomatitis - Oral Mucosal Lesion

Contributors: Olivia A. Failla RN, BSN, Tori Diedring DO, Susan Burgin MD
Other Resources UpToDate PubMed

Synopsis

Chronic ulcerative stomatitis (CUS) is an ulcerative condition of the oral cavity with clinical and histologic similarities to oral lichen planus (OLP).

The main autoantigen of CUS is a 70-kDa epithelial nuclear protein known as chronic ulcerative stomatitis protein (CUSP). CUSP plays a critically important role in the normal development of the oral epithelium and skin. In CUS, immunoglobulin G (IgG) antibodies and, less commonly, immunoglobulin A (IgA antibodies), known as stratified epithelium-specific antinuclear antibodies (SES-ANAs), are directed toward this protein.

CUS has a predominantly female distribution (female-to-male ratio of 14:1), with a mean age of 61 years and a median age of 64 years at diagnosis. CUS presents most often in White (91.3%) followed by Black, Hispanic, and Asian populations.

The most common signs of the disease include erosions, white lesions / striae, erythema, ulcerations, and leukoplakia. Xerostomia, vesiculation with positive gingival Nikolsky's sign, and gingival recession may be seen. These findings may be accompanied by pain, a burning / stinging sensation, and difficulty eating.

Rarely, ocular involvement and cutaneous involvement have been reported.

The clinical course of CUS is often relapsing and remitting.

Codes

ICD10CM:
K12.1 – Other forms of stomatitis

SNOMEDCT:
707268007 – Chronic ulcerative stomatitis

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Last Reviewed:10/05/2022
Last Updated:10/12/2022
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Chronic ulcerative stomatitis - Oral Mucosal Lesion
A medical illustration showing key findings of Chronic ulcerative stomatitis
Copyright © 2024 VisualDx®. All rights reserved.