Sudden conjunctivitis, lymphopenia, and rash combined with hemodynamic changes
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Synopsis
The hallmark mucocutaneous manifestations of SCoRCH include conjunctivitis, generalized erythema, and mild acral and facial edema. The eruption may be pruritic. These findings are accompanied by tachycardia, and hypotension and shock requiring vasopressors may be seen. Fever is commonly associated. Acute kidney injury and transaminitis may be present, and lymphopenia is common. Aseptic meningitis and respiratory failure have been reported as isolated reactions to TMP-SMX as well as in the setting of SCoRCH.
In people with no prior exposure to TMP-SMX, onset occurs 4-11 days after drug exposure, but in those with a history of TMP-SMX exposure, onset can occur within 1 day of re-exposure.
Codes
T37.0X5A – Adverse effect of sulfonamides, initial encounter
SNOMEDCT:
876798004 – Adverse reaction to sulfamethoxazole and/or trimethoprim
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Last Updated:07/30/2023