Cutaneous mucoepidermoid carcinoma is an extremely rare malignant tumor of mucus-secreting and epidermoid components of the skin. It is thought to arise de novo or from nevus sebaceus, sweat glands, or ectopic salivary glands. Clinically, cutaneous mucoepidermoid carcinoma resembles basal cell carcinoma. Most cases are diagnosed in patients of Northern European descent with a slight predilection for males and patients of older age (mean age of 63.4 years). The face is the most common site.

Cutaneous mucoepidermoid carcinoma is considered a low-grade neoplasm with limited metastatic potential. However, it is important to differentiate primary carcinoma from metastatic mucoepidermoid carcinoma originating from distant glandular structures.