Eosinophilic cellulitis, or Wells syndrome, is a rare disorder of unknown etiology. Eosinophilic cellulitis is reported infrequently in children and is manifested by eosinophil infiltration in the dermis.

Eosinophilic cellulitis presents with sudden onset of single or multiple mildly painful or pruritic, erythematous plaques. The lesions are usually seen on the extremities but may be anywhere on the skin and are typically symmetric or widespread. Uncommonly, fever and arthralgias are present. Spontaneous resolution tends to occur over 4-8 weeks. Recurrences may occur. Familial cases have been reported.

Cases may be associated with insect bites, viral infections, parasite infestations, fungal infections, vaccination, and hypersensitivity reactions. More rarely, leukemia, eosinophilic granulomatosis with polyangiitis, and hypereosinophilic syndrome have been reported.