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Demyelinating sensorimotor neuropathy
Other Resources UpToDate PubMed

Demyelinating sensorimotor neuropathy

Contributors: Andrea Wasilewski MD, Jamie Adams MD, Richard L. Barbano MD, PhD
Other Resources UpToDate PubMed

Synopsis

A demyelinating sensorimotor neuropathy is a peripheral nerve dysfunction caused by loss of myelination around the axons of neurons. Demyelinating neuropathies cause motor, sensory, or autonomic symptoms. Demyelinating neuropathies affect large diameter axons first, initially producing motor weakness, loss of vibratory sensation, and decreased proprioception.

Demyelinating neuropathies may have an acute or chronic onset. Demyelination can be caused by autoimmune disease, toxins, drug side effects, nutritional deficiencies, infections, paraneoplastic syndromes, or congenital disorders. Charcot-Marie-Tooth disease is the most common cause of hereditary demyelinating polyneuropathy.

Age of onset and treatment vary according to the underlying cause of the neuropathy.

Codes

ICD10CM:
G60.8 – Other hereditary and idiopathic neuropathies

SNOMEDCT:
230656003 – Demyelinating sensorimotor neuropathy

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

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Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

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References

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Last Reviewed:11/01/2018
Last Updated:11/01/2018
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Demyelinating sensorimotor neuropathy
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A medical illustration showing key findings of Demyelinating sensorimotor neuropathy : Distal muscle weakness, Hyporeflexia
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